University of Illinois Urbana-Champaign

Layer 5 and 6 neurons projecting to the inferior colliculus comprise two distinct and heterogeneous populations in the cortex

Yudintsev, Georgiy; Llano, Daniel A.

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ARO_2017_Poster_Gosha_56 by 42 in.pdf

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https://hdl.handle.net/2142/95194

Description

Title
Layer 5 and 6 neurons projecting to the inferior colliculus comprise two distinct and heterogeneous populations in the cortex
Author(s)
  • Yudintsev, Georgiy
  • Llano, Daniel A.
Issue Date
2017-02-13
Keyword(s)
  • Auditory cortex
  • Cortex
  • Inferior colliculus
  • Top-down projections
  • Descending auditory system
  • In vivo imaging
Date of Ingest
2017-02-21T15:49:24Z
Abstract
Top-down modulation is a powerful mechanism by which the brain can disambiguate signals arriving at the sensory periphery, and descending projections are believed to be an important anatomical substrate by which this modulation may occur. One of such projections - the corticocollicular projection - has recently garnered much attention due to its potential to alter response properties of cells in the inferior colliculus (IC). However, the anatomical organization of this pathway remains poorly understood. The corticocollicular neurons emanate from two distinct bands of the auditory cortex - layer 5 and deep layer 6 - and differ in their morphology and biophysical properties. The current mouse study from our laboratory demonstrates significant heterogeneity in the global distributions of layer 5 and 6 corticocollicular neurons, with layer 6 generally covering a broader area of the cortex than layer 5. As confirmed by more detailed analysis of serial reconstructions obtained in Neurolucida, we found that layer 6 cellular distribution is centered more ventrally and anteriorly than layer 5, also forming a rostro-ventral area in the cortex consisting only of layer 6 cells. Combining in vivo imaging in GCaMP mice, followed by a retrograde tracer injection and post-hoc anatomical reconstructions, we found the rostro-ventral area of layer 6 cells to be acoustically irresponsive to pure tones, noise or species specific mouse calls. Further small injections of an anterograde tracer (BDA) or retrograde tracer (CTb) into this area revealed its connections with the amygdala and a number of subcortical structures, including paralaminar thalamic nuclei. These data extend previous findings that suggest that layer 5 and layer 6 corticocollicular projections have different organizations and, presumably, different roles in modifying inferior colliculus function.
Type of Resource
  • text
  • image
Genre of Resource
Conference Poster
Language
en
Permalink
http://hdl.handle.net/2142/95194
Sponsor(s)/Grant Number(s)
NIDCD R01 DC013073 02

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