University of Illinois Urbana-Champaign

The chemical and enzymatic synthesis of poly(ADP-ribose)

Lambrecht, Michael

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https://hdl.handle.net/2142/92923

Description

Title
The chemical and enzymatic synthesis of poly(ADP-ribose)
Author(s)
Lambrecht, Michael
Issue Date
2016-07-06
Director of Research (if dissertation) or Advisor (if thesis)
Hergenrother, Paul J.
Doctoral Committee Chair(s)
Hergenrother, Paul J.
Committee Member(s)
  • Silverman, Scott K.
  • Mitchell, Douglas A.
  • Sarlah, David
Department of Study
Chemistry
Discipline
Chemistry
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
  • Poly(ADP-ribose)
  • Total Synthesis
  • Enzymatic Synthesis
  • Poly(ADP-ribose) Polymerase
  • Poly ADP ribose polymerase (PARP)
  • Poly(ADP-ribose) Glycohydrolase (PARG)
  • Raptinal
Abstract
Poly(ADP-ribose) synthesis and degradation are important cellular processes associated with the DNA damage response and many other pathways. Traditionally, these processes have been challenging to study due to the heterogeneity associated with the synthesis of poly(ADP-ribose). Discussed here are methods for the synthesis of homogeneous poly(ADP-ribose) as well as the biology that is enabled by these synthetic efforts.
Graduation Semester
2016-08
Type of Resource
text
Permalink
http://hdl.handle.net/2142/92923
Copyright and License Information
Copyright 2016 Michael Lambrecht

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