The transgenerational effects of prenatal BPA exposure on gonadal development and behavior

Salter, Rekia

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https://hdl.handle.net/2142/91661 Copy

Description

Title

The transgenerational effects of prenatal BPA exposure on gonadal development and behavior

Author(s)

Salter, Rekia

Issue Date

2016-07-15

Keyword(s)

• Transgenerational Effects of Bisphenol A
• Bisphenol A

Abstract

This study tested the hypothesis that prenatal Bisphenol A (BPA) may have a trans generationally effects on gonadal development and cognitive behavior (memory and anxiety) in male mice. Prenatal exposure was done by orally dosing pregnant female CD-1 mice with tocopherol-stripped corn oil (vehicle control) or BPA (0.5 μg/kg/day, 20 μg/kg/day, 50 μg/kg/day) from gestation day 11 to birth. Histology of the testis was performed on the F1 generation at the ages of postnatal day (PND) 60 and Postnatal month (PNM) 15 to determine the impact of prenatal BPA exposure to gonadal development. The F3 generation at 10 months of age had their fertility was assessed. Serum testosterone levels were measured at the age of 11 months. The F3 generation was also tested in cognitive behavior through open field, novel object, and elevated plus maze testing at 11 months of age. F1 generation mice that were exposed to BPA doses (.5 – 50 μg/kg/day) exhibited slight gonadal abnormities in PND 60. However, at age of 15 months obvious histopathological abnormalities and defects were observed. In the F3 generation only mice exposed to the low dose (.5 μg/kg/day) displayed significantly lower fertility. The two high dose groups (20-50 μg/kg/day) were found to have significantly lower serum testosterone levels. F3 generation mice exposed to (.5 – 50 μg/kg/day) demonstrated significantly less memory function. However only the two high dose groups (20-50 μg/kg/day) displayed significantly more anxiety. This study found that a prenatal exposure to BPA is transgenerational and may give a lifelong impact on male fertility, testosterone level and cognitive behavior.

Type of Resource

other

Language

en

Permalink

http://hdl.handle.net/2142/91661

Copyright and License Information

Copyright 2016 Rekia Salter

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