WHAT CAN WE EXPECT OF HIGH-RESOLUTION SPECTROSCOPIES ON CARBOHYDRATES?

Cocinero, Emilio J.

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https://hdl.handle.net/2142/79083 Copy

Description

Title

WHAT CAN WE EXPECT OF HIGH-RESOLUTION SPECTROSCOPIES ON CARBOHYDRATES?

Author(s)

Cocinero, Emilio J.

Contributor(s)

• Davis, Benjamin G.
• Lesarri, Alberto
• Basterretxea, Francisco J.
• Fernández, José A.
• Usabiaga, Imanol
• Uriarte, Iciar
• Ecija, Patricia

Issue Date

24-Jun-15

Keyword(s)

Plenary

Abstract

begin{wrapfigure}{l}{0pt} includegraphics[scale=0.6]{ribofuranose.eps} end{wrapfigure} Carbohydrates are one of the most multifaceted building blocks, performing numerous roles in living organisms. We present several structural investigations on carbohydrates exploiting an experimental strategy which combines microwave (MW) and laser spectroscopies in high-resolution. Laser spectroscopy offers high sensitivity coupled to mass and conformer selectivity, making it ideal for polysaccharides studies. On the other hand, microwave spectroscopy provides much higher resolution and direct access to molecular structure of monosaccharides. This combined approach provides not only accurate chemical insight on conformation, structure and molecular properties, but also benchmarking standards guiding the development of theoretical calculations. In order to illustrate the possibilities of a combined MW-laser approach we present results on the conformational landscape and structural properties of several monosaccharidesfootnote{E.J. Cocinero, A. Lesarri, P. '{E}cija, F.J. Basterretxea, J.-U. Grabow, J.A. Fern'{a}ndez and F. Casta~{n}o textit{Angew. Chem. Int. Ed.} textbf{51}, 3119-3124, 2012.}$^{,}$footnote{E.J. Cocinero, A. Lesarri, P. '{E}cija, '{A}. Cimas, B.G. Davis, F.J. Basterretxea, J.A. Fern'{a}ndez and F. Casta~{n}o textit{J. Am. Chem. Soc.} textbf{135}, 2845-2852, 2013.} and oligosaccharides including microsolvation and molecular recognition processes of carbohydrates.footnote{E.J. Cocinero, P. c{C}arc{c}abal, T.D. Vaden, J.P. Simons and B.G. Davis textit{Nature} textbf{469}, 76-80, 2011.}$^{,}$footnote{C.S. Barry, E.J. Cocinero, P. c{C}arc{c}abal, D.P. Gamblin, E.C. Stanca-Kaposta, S. M. Fern'{a}ndez-Alonso, S. Rudi'{c}, J.P. Simons and B.G. Davis textit{J. Am. Chem. Soc.} textbf{135}, 16895-16903, 2013.}

Publisher

International Symposium on Molecular Spectroscopy

Type of Resource

text

Language

English

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http://hdl.handle.net/2142/79083

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