Characterization of the Anti-Inflammatory Effects of the Molluscum Contagiosum Virus MC160 Protein
Nichols, Daniel B.
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Permalink
https://hdl.handle.net/2142/88341
Description
Title
Characterization of the Anti-Inflammatory Effects of the Molluscum Contagiosum Virus MC160 Protein
Author(s)
Nichols, Daniel B.
Issue Date
2008
Doctoral Committee Chair(s)
Joanna Shisler
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
Biology, Virology
Language
eng
Abstract
Using a series of MC160 deletion mutant proteins, we found that two distinct regions of the MC160 protein independently inhibit TNF-mediated NF-kappaB activation. Specifically, we observed that the second DED of MC160 interacts with procaspase-8 as a means to inhibit NF-kappaB activation, while the C-terminus of MC160 interacts with the chaperone Hsp90. Because both procaspase-8 and Hsp90 associate with the IKK complex, we believe that the MC160 protein binds these proteins as a means to destabilize the IKK complex, resulting in reduced IKK activation, and ultimately, inhibition of NF-kappaB activation.
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