Supramolecular Architectures in Molecular Medicine: Visualizing and Manipulating the Structure of Protein-Lipid Surfaces
Carlson, Joseph Woodward
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Permalink
https://hdl.handle.net/2142/87915
Description
Title
Supramolecular Architectures in Molecular Medicine: Visualizing and Manipulating the Structure of Protein-Lipid Surfaces
Author(s)
Carlson, Joseph Woodward
Issue Date
1999
Doctoral Committee Chair(s)
Sligar, Stephen G.
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
Health Sciences, Pharmacology
Language
eng
Abstract
In separate studies, myoglobin has been used to study the fluorescence lifetime behavior of oriented biomolecular surfaces. These studies have revealed differences in lifetime between differentially oriented myoglobin molecules, consistent with differential accessibility of the heme pocket to quenching by oxygen. A computational study of the dependence of linear dichroism on the distribution of protein orientation angle has revealed a constrained degenerate solution, which has impact on all attempts to describe protein orientation with this technique.
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