Synaptic Plasticity in the Cerebral Cortex of Fragile X Knockout Mice
Grossman, Aaron William
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Permalink
https://hdl.handle.net/2142/87870
Description
Title
Synaptic Plasticity in the Cerebral Cortex of Fragile X Knockout Mice
Author(s)
Grossman, Aaron William
Issue Date
2006
Doctoral Committee Chair(s)
Greenough, William T.
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
Health Sciences, Medicine and Surgery
Language
eng
Abstract
In the next experiments, the ultrastructure of the visual cortex was examined in young Fmr1 knockout and wildtype mice. The rate of developmental synaptogenesis between the two genotypes was similar, but Fmr1 knockout mice exhibited levels of synaptic protein synthesis lower than those of wildtype mice. The role of FMRP in experience-dependent brain plasticity was also assessed. FMRP expression in the rat occipital cortex increases following exposure to a complex environment, but measures of synaptogenesis in Fmr1 knockout mice raised in this environment have been inconclusive. FMRP appears to be important for some, but not all forms of synaptic plasticity.
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