The Role of Ultrasound Contrast Agents in Producing Sonoporation
Forbes, Monica Mary
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Permalink
https://hdl.handle.net/2142/87846
Description
Title
The Role of Ultrasound Contrast Agents in Producing Sonoporation
Author(s)
Forbes, Monica Mary
Issue Date
2009
Doctoral Committee Chair(s)
O'Brien, William D.
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
Engineering, Biomedical
Language
eng
Abstract
This dissertation successfully elucidated the physical mechanism of sonoporation. Oscillation of UCAs near a cell produced microstreaming that resulted in shear stress on the cell membranes. This shear stress resulted in sonoporation, a permeability change that allowed for the uptake of macromolecules into the cells.
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