University of Illinois Urbana-Champaign

Farnesyl Pyrophosphate/geranylgeranyl Pyrophosphate Synthase of Toxoplasma Gondii: Its Role in the Parasite Isoprenoid Pathway and as a Target for Bisphosphonates

Ling, Yan

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https://hdl.handle.net/2142/87630

Description

Title
Farnesyl Pyrophosphate/geranylgeranyl Pyrophosphate Synthase of Toxoplasma Gondii: Its Role in the Parasite Isoprenoid Pathway and as a Target for Bisphosphonates
Author(s)
Ling, Yan
Issue Date
2005
Doctoral Committee Chair(s)
Silvia N.J.Moreno
Department of Study
Veterinary Pathobiology
Discipline
Veterinary Pathobiology
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
Biology, Cell
Language
eng
Abstract
In summary, this work provides information to understand the isoprenoid pathway in T. gondii by isolation and characterization of an important enzyme in the pathway, TgFGGPS. Identification of TgFGGPS as the molecular target of bisphosphonates in this work provides a key tool for rational-based drug design. In addition, this work represents a new approach to chemotherapy of toxoplasmosis with a group of safe and easy to prepare compounds.
Graduation Semester
2005
Type of Resource
text
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http://hdl.handle.net/2142/87630

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Dissertations and Theses - Pathobiology