Molecular Responses to Desialylation in a Rat Model of Induced Glomerulopathy
Ringenberg, Michael Alan
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https://hdl.handle.net/2142/87620
Description
Title
Molecular Responses to Desialylation in a Rat Model of Induced Glomerulopathy
Author(s)
Ringenberg, Michael Alan
Issue Date
2002
Doctoral Committee Chair(s)
Vimr, Eric R.
Department of Study
Veterinary Pathobiology
Discipline
Veterinary Pathobiology
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
Biology, Animal Physiology
Language
eng
Abstract
In this study, adaptation of a previously described in vivo model of neuraminidase-induced glomerular injury is described in the rat. Information derived from the initial pilot studies has been used to formulate the hypothesis that loss of glomerular sialic acid, concomitant with functional glomerular damage, results in a re-sialylation event associated with sequentially increased levels of glomerular linkage-specific sialyltransferase transcript levels and activity. The results of these experiments provide insight into specific molecular responses of podocytes to injury, in addition to demonstrating the versatility of this animal model for descriptive and mechanistic studies regarding podocyte sialobiology.
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