Multiple Genetic Loci Control Susceptibility and Disease Characteristics in Murine Experimental Allergic Encephalomyelitis
Butterfield, Russell James
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https://hdl.handle.net/2142/87617
Description
Title
Multiple Genetic Loci Control Susceptibility and Disease Characteristics in Murine Experimental Allergic Encephalomyelitis
Author(s)
Butterfield, Russell James
Issue Date
2001
Doctoral Committee Chair(s)
Schook, Lawrence B.
Department of Study
Veterinary Pathobiology
Discipline
Veterinary Pathobiology
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
Health Sciences, Immunology
Language
eng
Abstract
We identified 21 regions of the mouse genome that control EAE susceptibility, disease subtype, and clinical or histological disease parameters. Our results suggest that different clinical subtypes of EAE are immunogenetically distinct. In addition, the severity, duration, and day of onset are genetically controlled. Lesion characteristics and location of lesions are modulated by numerous genetic factors and can be influenced by sex. Underlying genetic differences may explain the heterogeneity in disease course and prognosis among MS patients. In light of our findings, MS genetic studies should be stratified more stringently with respect to sex, lesion characteristics, and disease subtype.
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