Integrated Entrainment of the Suprachiasmatic Clock by the Two Neurotransmitters of the Retinohypothalamic Tract, Glutamate and PACAP
Dong, Chen
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https://hdl.handle.net/2142/87267
Description
Title
Integrated Entrainment of the Suprachiasmatic Clock by the Two Neurotransmitters of the Retinohypothalamic Tract, Glutamate and PACAP
Author(s)
Dong, Chen
Issue Date
1999
Doctoral Committee Chair(s)
Gillette, Martha U.
Department of Study
Molecular and Integrative Physiology
Discipline
Molecular and Integrative Physiology
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
Biology, Molecular
Language
eng
Abstract
The functional interaction between PACAP and Glu was then investigated. PACAP blocked the phase advance normally induced by Glu at late night, while anti-PACAP reagents augmented the Glu-induced phase advance in the SCN slice as well as the light-induced phase advance in vivo. In the early night, PACAP enhanced Glu-induced delay while PACAP antagonists inhibited it. Anti-PACAP reagents also decreased the basal level of cAMP suggesting a tonic release of PACAP. Thus, through the interplay of an amino acid neurotransmitter and a large peptide neurotransmitter, the RHT signals fine-tune the phase of the SCN clock to the surrounding light/dark cycle. This finding provides insight as to how monotonic sensory signal is transformed into a modulated, adaptive behavioral response.
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