Insulin-Like Growth Factor-1 Regulation and Subunit Composition of Low-Voltage Activated Calcium Channels in Atrial Myocytes
Chen, Chien-Chang
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https://hdl.handle.net/2142/87264
Description
Title
Insulin-Like Growth Factor-1 Regulation and Subunit Composition of Low-Voltage Activated Calcium Channels in Atrial Myocytes
Author(s)
Chen, Chien-Chang
Issue Date
1998
Doctoral Committee Chair(s)
Best, Philip M.
Department of Study
Molecular and Integrative Physiology
Discipline
Molecular and Integrative Physiology
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
Biology, Animal Physiology
Language
eng
Abstract
To test whether the LVA Ca$\sp{2+}$ channel contains $\beta$ subunit, I studied the ability of an AS ON $(\rm\beta\sb{all})$ targeting a common sequence of all four $\beta$ subunits to modulate the LVA Ca$\sp{2+}$ current in atrial myocytes. Our data showed that LVA Ca$\sp{2+}$ channels were inhibited by AS-$\rm\beta\sb{all}.$ These results support the idea that atrial T-type calcium channel is encoded by a member of the $\rm\alpha\sb{1E}$ calcium channel genes and is composed of at least the $\rm\alpha\sb{1E}$ and $\beta$ subunits.
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