Developmentally Related Increased Seizure Susceptibility to Pentylenetetrazole in Fragile X Knockout Mice
Campos, Victor E.
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Permalink
https://hdl.handle.net/2142/87248
Description
Title
Developmentally Related Increased Seizure Susceptibility to Pentylenetetrazole in Fragile X Knockout Mice
Author(s)
Campos, Victor E.
Issue Date
2008
Doctoral Committee Chair(s)
Best, Philip M.
Department of Study
Molecular and Integrative Physiology
Discipline
Molecular and Integrative Physiology
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Date of Ingest
2015-09-28T15:50:13Z
Keyword(s)
Biology, Molecular
Language
eng
Abstract
These experiments have demonstrated that fragile X knockout mice are more susceptible than control animals to the chemoconvulsant PTZ as adults, but not as juveniles. Furthermore, the temporal progression suggests that there is a developmental involvement in this seizure susceptibility. The mechanism of the seizure susceptibility and temporal progression are areas for further study. With a greater understanding of this general hyperexcitability, more effective treatments for fragile X patients can be devised.
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