Cross-Modulatory Actions of Estrogen Receptor Beta on Estrogen Receptor Alpha Transcriptional Activity in Breast Cancer Cells
Chang, Edmund Chi-Ru
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Permalink
https://hdl.handle.net/2142/87245
Description
Title
Cross-Modulatory Actions of Estrogen Receptor Beta on Estrogen Receptor Alpha Transcriptional Activity in Breast Cancer Cells
Author(s)
Chang, Edmund Chi-Ru
Issue Date
2007
Doctoral Committee Chair(s)
Katzenellenbogen, Benita S.
Department of Study
Molecular and Integrative Physiology
Discipline
Molecular and Integrative Physiology
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
Biology, Molecular
Language
eng
Abstract
Our observations indicate that the ability of ERalpha and ERbeta to serve as determinants of gene expression is greatly influenced by the nature of the ligand, ligand dose, and the ability of ligand-ER complexes to recruit coregulators at ER binding sites of hormone-regulated genes.
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