Estrogen Inducible Serpin, Proteinase Inhibitor 9, in Immunosurveillance and Apoptosis
Jiang, Xinguo
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https://hdl.handle.net/2142/87244
Description
Title
Estrogen Inducible Serpin, Proteinase Inhibitor 9, in Immunosurveillance and Apoptosis
Author(s)
Jiang, Xinguo
Issue Date
2007
Doctoral Committee Chair(s)
Shapiro, David J.
Department of Study
Molecular and Integrative Physiology
Discipline
Molecular and Integrative Physiology
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
Chemistry, Biochemistry
Language
eng
Abstract
The phytoestrogen genistein has attracted a great deal of recent interest. In MCF-7 cells, we find that 10 nM genistein induces PI-9 as effectively as saturating E2, and genistein treated MCF-7 cells are resistant to NK cell mediated cytotoxicity. In ERalphaHA cells, the dose response curves for induction of PI-9 by E2 and by genistein are nearly identical and inducing PI-9 with genistein blocks NK cell mediated killing. Analysis of MCF-7 tumors produced in a mouse xenograft model shows that genistein, soy-products including soy flour and NovasoyRTM induce PI-9 expression in vivo. Our data highlight the possibility that low concentrations of genistein might promote growth of pre-existing estrogen receptor-dependent breast cancer.
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