Cholinergic Regulation of the Mammalian Circadian System: Phase Shifting in Vivo and in Vitro in Wildtype and M(1) Knockout Mice Induced by Cholinergic Agonists
Buchanan, Gordon Frank
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https://hdl.handle.net/2142/87226
Description
Title
Cholinergic Regulation of the Mammalian Circadian System: Phase Shifting in Vivo and in Vitro in Wildtype and M(1) Knockout Mice Induced by Cholinergic Agonists
Author(s)
Buchanan, Gordon Frank
Issue Date
2003
Doctoral Committee Chair(s)
Gillette, Martha U.
Department of Study
Molecular and Integrative Physiology
Discipline
Molecular and Integrative Physiology
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
Biology, Neuroscience
Language
eng
Abstract
These experiments demonstrate that ACh regulates the circadian clock via at least two different pathways. One induces phase advances throughout the night and is mediated via the M1AChR. The other causes a biphasic, light-like response and is not mediated via the M1AChR.
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