Isolation and Characterization of Novel Estrogen Binding Proteins: Physiological Implications
Kipp, Jingjing Liu
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https://hdl.handle.net/2142/87218
Description
Title
Isolation and Characterization of Novel Estrogen Binding Proteins: Physiological Implications
Author(s)
Kipp, Jingjing Liu
Issue Date
2002
Doctoral Committee Chair(s)
Ramirez, Victor D.
Department of Study
Molecular and Integrative Physiology
Discipline
Molecular and Integrative Physiology
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
Biology, Neuroscience
Language
eng
Abstract
In summary, I have demonstrated the effect of estrogen and estrogen-like compounds on mitochondrial membrane-bound F0F1-ATPase and my efforts to isolate and identify cell membrane estrogen receptor have led me to discover a novel physiologically relevant estrogen binding protein: tubulin. Tubulin shows high affinity for estradiol and for testosterone, and these two steroid hormones modulate microtubule polymerization in an opposite manner. These findings add new information to our understanding of the non-genomic effects of steroid hormones mediated through those two novel estrogen/testosterone binding proteins.
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