Estrogen Receptors: Interaction With Estrogen Response Elements and Estrogen Receptor-Associated Proteins
Loven, Margaret Anne
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https://hdl.handle.net/2142/87216
Description
Title
Estrogen Receptors: Interaction With Estrogen Response Elements and Estrogen Receptor-Associated Proteins
Author(s)
Loven, Margaret Anne
Issue Date
2002
Doctoral Committee Chair(s)
Nardulli, Ann M.
Department of Study
Molecular and Integrative Physiology
Discipline
Molecular and Integrative Physiology
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
Biology, Molecular
Language
eng
Abstract
Since DNA-induced conformational changes in estrogen receptors affected recruitment of transcriptional coregulatory proteins, we examined differential recruitment of novel proteins. One novel protein was isolated and identified by protein sequencing as TAF-I beta, a protein previously implicated in acetylation, transcription and phosphorylation. TAF-I beta not only associates with ER in a cell environment, but also inhibits acetylation of histones and ER alpha in vitro and decreases ER alpha acetylation in vivo. Therefore, TAF-I beta may alter ER-mediated transcription by changing acetylation of ER or histones or both. Taken together, these data indicate that estrogen receptors associate with a variety of regulatory proteins and that interaction with these factors is affected both by an initial interaction with DNA and further modulated by receptor conformations induced by individual ERE sequences.
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