Interactions of Alpha-Synuclein With Phospholipids: Implications for Physiology and Neurodegenerative Disease
Perrin, Richard Justin
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Permalink
https://hdl.handle.net/2142/87215
Description
Title
Interactions of Alpha-Synuclein With Phospholipids: Implications for Physiology and Neurodegenerative Disease
Author(s)
Perrin, Richard Justin
Issue Date
2001
Doctoral Committee Chair(s)
David Forrest Clayton
Department of Study
Molecular and Integrative Physiology
Discipline
Molecular and Integrative Physiology
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
Biology, Molecular
Language
eng
Abstract
Viewed in the context of the literature (reviewed here), this work suggests that synuclein's membrane-based interaction with long-chain polyunsaturated phospholipids may be physiologically relevant to synaptic function, and further, may represent an early event in the development of neurodegenerative disease.
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