Effects of Gestational and Lactational Exposure to 2,3,7,8-Tetrachlorodibenzo-P-Dioxin or Coplanar PCBs on Reproductive Development and Sexually Dimorphic Behaviors in Rats

Amin, Shahid

Permalink

https://hdl.handle.net/2142/87136 Copy

Description

Title

Effects of Gestational and Lactational Exposure to 2,3,7,8-Tetrachlorodibenzo-P-Dioxin or Coplanar PCBs on Reproductive Development and Sexually Dimorphic Behaviors in Rats

Author(s)

Amin, Shahid

Issue Date

1998

Doctoral Committee Chair(s)

Schantz, Susan L.

Department of Study

Veterinary Clinical Medicine

Discipline

Veterinary Clinical Medicine

Degree Granting Institution

University of Illinois at Urbana-Champaign

Degree Name

Ph.D.

Degree Level

Dissertation

Keyword(s)

Biology, Anatomy

Language

eng

Abstract

In contrast sexually dimorphic non-reproductive behaviors were affected in TCDD and coplanar PCB exposed rats. In the initial study, the play behavior in TCDD exposed rats was suppressed. However in the follow-up study, when play behavior was tested with a different protocol than in the initial study, the effects were not replicated. The loss of effects could be due to the changes in the testing protocol, or it could be that because the effects on play behavior were marginal in the initial study, they did not appear in the follow-up study. Saccharin preference of the TCDD and coplanar PCBs exposed females was masculinized in both studies. TCDD and PCBs have antiestrogenic effects and masculinization of saccharin preference in females could be due to the antiestrogenic effects of these chemicals in the parabrachial nucleus of female rats.

Graduation Semester

1998

Type of Resource

text

Permalink

http://hdl.handle.net/2142/87136

Owning Collections