Factors and Mechanisms Involved in Epithelial Injury and Repair of Equine Colon
Rotting, Anna K.
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https://hdl.handle.net/2142/87132
Description
Title
Factors and Mechanisms Involved in Epithelial Injury and Repair of Equine Colon
Author(s)
Rotting, Anna K.
Issue Date
2005
Doctoral Committee Chair(s)
David E. Freeman
Department of Study
Veterinary Clinical Medicine
Discipline
Veterinary Clinical Medicine
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
Biology, Veterinary Science
Language
eng
Abstract
We concluded that acetylcysteine and glutamine might be beneficial in the treatment of horses with gastrointestinal disease. The increase of mucosal permeability caused by acetylcysteine may be caused by the mucolytic properties of acetylcysteine. A lower dose may prevent mucolysis while allowing for the beneficial effects of acetylcysteine. Eosinophils were involved in several disease processes of the gastrointestinal tract in horses. They may be part of an initial inflammatory response of gastrointestinal mucosa to injury, and could have detrimental effects in several diseases including ischemia/reperfusion.
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