Expression of Cytosolic and Mitochondrial Superoxide Dismutases: Their Role in the Chemoresistance of Malignant Melanoma
Sulaimon, Shola Shakirat
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https://hdl.handle.net/2142/87124
Description
Title
Expression of Cytosolic and Mitochondrial Superoxide Dismutases: Their Role in the Chemoresistance of Malignant Melanoma
Author(s)
Sulaimon, Shola Shakirat
Issue Date
2003
Doctoral Committee Chair(s)
Barbara E. Kitchell
Department of Study
Veterinary Clinical Medicine
Discipline
Veterinary Clinical Medicine
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
Biology, Cell
Language
eng
Abstract
In summary, MM cells that are exposed to sublethal doses of ROS generating chemotherapeutic agents are able to modulate antioxidant defenses as an adaptive response. By upregulating Mn-SOD without commensurate increase in catalase activities, an imbalance in oxidant processing occurs. This imbalance in the antioxidant defense system results in accumulation of peroxides, which can act as secondary messengers to enhance cell survival pathways.
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