Acute Effects of Episodic PCB Congeners on the Hypothalamo -Pituitary-Thyroid (Hpt) Axis in Weanling Female Rats
Khan, Moazzam Ali
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https://hdl.handle.net/2142/87112
Description
Title
Acute Effects of Episodic PCB Congeners on the Hypothalamo -Pituitary-Thyroid (Hpt) Axis in Weanling Female Rats
Author(s)
Khan, Moazzam Ali
Issue Date
2001
Doctoral Committee Chair(s)
Hansen, Larry G.
Department of Study
Veterinary Clinical Medicine
Discipline
Veterinary Clinical Medicine
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
Biology, Veterinary Science
Language
eng
Abstract
These studies demonstrate that brief exposure to ortho-substituted PCBs can cause alterations in the HPT axis in immature animals. The data indicate that ortho-PCBs 95 or 101 cause secondary or pituitary-related hypothyroidism. There is also evidence that these PCBs may be affecting the HPT-axis through multiple mechanisms.
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