The Design and Analysis of Pediatric Vaccine Formularies: Theory and Practice
Hall, Shane Nikolaus
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https://hdl.handle.net/2142/87081
Description
Title
The Design and Analysis of Pediatric Vaccine Formularies: Theory and Practice
Author(s)
Hall, Shane Nikolaus
Issue Date
2006
Doctoral Committee Chair(s)
Jacobson, Sheldon H.
Department of Study
Industrial Engineering
Discipline
Industrial Engineering
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
Health Sciences, Public Health
Language
eng
Abstract
The first problem models a general childhood immunization schedule to design a vaccine formulary that minimizes the cost of fully immunizing a child. The second problem models a general childhood immunization schedule to design a vaccine formulary that safely immunizes a child against several infectious diseases by restricting or limiting extraimmunization (i.e., extra doses of vaccine). These problems are vitally important since the cost of vaccinating a child contributes to the underimmunization of children, and extraimmunization poses biological risks, amplifies philosophical concerns with vaccination, and creates an unnecessary economic burden on society. These models are rigorously analyzed and several algorithms---both exact and heuristic---are presented. Furthermore, a computational comparison of these algorithms is presented for the 2006 Recommended Childhood Immunization Schedule as well as several randomly generated childhood immunization schedules. The third problem combines the first two problems by modeling a general childhood immunization schedule to design a vaccine formulary that minimizes the cost of fully immunizing a child while restricting or limiting extraimmunization. The results reported here provide both fundamental insights to the operations research community as well as practical value for the public health community.
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