Fatty Acid and Biotin Metabolism in Escherichia Coli
Subrahmanyam, Satyanarayana
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https://hdl.handle.net/2142/86739
Description
Title
Fatty Acid and Biotin Metabolism in Escherichia Coli
Author(s)
Subrahmanyam, Satyanarayana
Issue Date
1998
Doctoral Committee Chair(s)
Cronan, John E., Jr
Department of Study
Microbiology
Discipline
Microbiology
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
Chemistry, Biochemistry
Language
eng
Abstract
Biotin which is essential for the synthesis of fatty acids in E. coli is thought to be derived from a modified fatty acid pathway. In experiments used to verify this hypothesis I discovered a new intermediate in biotin synthesis. This intermediate `X', was purified from the spent growth medium of strain sup151 (isolated as a bypass suppressor of a bioH mutation). Genetic data suggests that this intermediate is made by the action of the bioH and bioC gene products and its production is repressed by high levels of biotin in the growth medium via the BirA protein.
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