Characterization of the Glycosylation and Signal Peptide Sequences Within the Vaccinia Virus M2 Protein and Influence on ERK1/2 and Nf-Kappab Activation
Hinthong, Olivia
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https://hdl.handle.net/2142/86716
Description
Title
Characterization of the Glycosylation and Signal Peptide Sequences Within the Vaccinia Virus M2 Protein and Influence on ERK1/2 and Nf-Kappab Activation
Author(s)
Hinthong, Olivia
Issue Date
2010
Doctoral Committee Chair(s)
Joanna Shisler
Department of Study
Microbiology
Discipline
Microbiology
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
Biology, Virology
Language
eng
Abstract
This dissertation elaborates on M2's molecular functioning as a viral immunomodulator to inhibit both the ERK1/2 and NF-kappaB pathways, which is reliant on its glycosylation status and proper cellular trafficking within the infected cell. As M2 has no homology to any known viral or cellular protein, this suggests a novel immunoregulatory function. Data contained within this dissertation provides insight into the molecular mechanism of an ER-localized protein, and its impact on cytoplasmic signaling pathways within the context of an anti-viral immune response.
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