Cloning, Phenotypic, and Experimental Analysis of Pat-4: The Caenorhabditis Elegans Homologue of Integrin -Linked Kinase
Mackinnon, Alexander Craig, Jr
This item is only available for download by members of the University of Illinois community. Students, faculty, and staff at the U of I may log in with your NetID and password to view the item. If you are trying to access an Illinois-restricted dissertation or thesis, you can request a copy through your library's Inter-Library Loan office or purchase a copy directly from ProQuest.
Permalink
https://hdl.handle.net/2142/86673
Description
Title
Cloning, Phenotypic, and Experimental Analysis of Pat-4: The Caenorhabditis Elegans Homologue of Integrin -Linked Kinase
Author(s)
Mackinnon, Alexander Craig, Jr
Issue Date
2004
Doctoral Committee Chair(s)
Benjamin D. Williams
Department of Study
Microbiology
Discipline
Microbiology
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
Biology, Cell
Language
eng
Abstract
"The third chapter describes experimental analysis of pat-4 during the morphogenesis of the excretory canal cell. By completely removing pat-4 expression from the excretory cell, I demonstrate that pat-4 is essential for the active outgrowth and complete extension of the excretory canal processes during embryogenesis and early larval development. Interestingly, ""kinase-dead"" and PH domain-disrupted forms of PAT-4/ILK support initial canal outgrowth. However, these canals frequently fail to fully extend during active canal outgrowth resulting in shortened, misshaped mature canals. These results identify a new developmental function for PAT-4/ILK in C. elegans and directly establish a role for ILK during the dynamic process of cellular morphogenesis in vivo ."
Use this login method if you
don't
have an
@illinois.edu
email address.
(Oops, I do have one)
IDEALS migrated to a new platform on June 23, 2022. If you created
your account prior to this date, you will have to reset your password
using the forgot-password link below.
