Identification, Characterization and Mechanism of the Estrogen Regulation of the Gene Encoding the Sodium /Hydrogen Exchanger -Regulatory Factor (nhe-Rf)
Ediger, Tracy Rene
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https://hdl.handle.net/2142/86642
Description
Title
Identification, Characterization and Mechanism of the Estrogen Regulation of the Gene Encoding the Sodium /Hydrogen Exchanger -Regulatory Factor (nhe-Rf)
Author(s)
Ediger, Tracy Rene
Issue Date
2002
Doctoral Committee Chair(s)
Katzenellenbogen, Benita S.
Department of Study
Microbiology
Discipline
Microbiology
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
Biology, Animal Physiology
Language
eng
Abstract
"Finally, studies were designed to help define the physiological role of estrogen-induction of the NHE-RF gene using two model systems. Immunocytochemistry was used to visualize NHE-RF in MCF-7 cells. Secondly, we created adenovirus that express the wild type or anti-sense NHE-RF RNA. By infecting cells with the adenovirus we may overexpress or functionally ""knock out"" the NHE-RF protein and monitor the resulting effects on cell signaling, fluid exchange and cell cytoarchitecture."
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