Regulation of Cell Migration by Integrin -Mediated Adhesion
Cox, Elisabeth Abbot
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https://hdl.handle.net/2142/86634
Description
Title
Regulation of Cell Migration by Integrin -Mediated Adhesion
Author(s)
Cox, Elisabeth Abbot
Issue Date
2001
Doctoral Committee Chair(s)
Anna Huttenlocher
Department of Study
Microbiology
Discipline
Microbiology
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
Biology, Cell
Language
eng
Abstract
The second project focused on identifying new molecules involved in regulating integrin-mediated adhesion during cell migration. The technique of mammalian cDNA expression cloning was used to identify regulators of cell-substratum adhesion. Through this approach, a cDNA with homology to RACK1, a receptor for activated protein kinase C, was identified. Interestingly, this cDNA was found to be a truncated form of RACK1 that has one of the putative PKC binding sites, but lacks C-terminal sequences required to bind integrin beta cytoplasmic tails, and the tyrosine kinase, Src. Characterization of this molecule has demonstrated that RACK1, through its interaction with Src, plays an important role in regulating cell adhesion, protrusion, and directional cell migration.
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