Characterization of Novel Neuronal Antigens in the Central Nervous System of Manduca Sexta
Wang, Chiou-Miin
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https://hdl.handle.net/2142/86484
Description
Title
Characterization of Novel Neuronal Antigens in the Central Nervous System of Manduca Sexta
Author(s)
Wang, Chiou-Miin
Issue Date
2000
Doctoral Committee Chair(s)
Fahrbach, Susan E.
Department of Study
Entomology
Discipline
Entomology
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
Biology, Entomology
Language
eng
Abstract
The predicted amino acid sequence of Ms-golgin80 is similar to several members of a growing family of coiled-coil, Golgi-associated proteins, including GM-130 and golgin-95. The Drosophila and Caenorhabditis elegans homologs of Ms-golgin80 were also identified through homology sequence search. These proteins share a characteristic feature of having extensive domains for the formation of coiled-coil structure to form a head-rod like molecule. The presence of Ms-golgin80 in mitotic neuroblasts and ganglion mother cells and its reduced expression in their differentiated neuronal progeny suggests that this protein may be involved in maintaining the mitotic property of mitotic cells through active vesicle transport in the Golgi complex.
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