A Mis-Expression Screen Identifies a PKA -Anchoring Protein in Antenna Lobe Development
Zhang, Dongsheng
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https://hdl.handle.net/2142/86319
Description
Title
A Mis-Expression Screen Identifies a PKA -Anchoring Protein in Antenna Lobe Development
Author(s)
Zhang, Dongsheng
Issue Date
2008
Doctoral Committee Chair(s)
Huey Hing
Department of Study
Cell and Developmental Biology
Discipline
Cell and Developmental Biology
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
Biology, Neuroscience
Language
eng
Abstract
One of the genes recovered was the Drosophila A Kinase anchoring protein 200 (Akap200). This thesis discusses the further characterization of this gene. Akap200 is a Protein Kinase A (PKA) binding protein with multiple binding sites for other signaling molecules, including Protein Kinase C (PKC), Camodulin and F-actin. Further studies showed that ORN axons of the Akap200 mutants stall in the path to their targets. The loss of Akap200 has different effects on different classes of ORN axons. These findings provide new insights into the molecular mechanisms underlying ORN axon targeting.
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