Isolation and Characterization of a Novel Gene, xMADML, Involved in Xenopus Laevis Eye Development Using Cornea -Lens Regeneration
Elkins, Matthew Brian
This item is only available for download by members of the University of Illinois community. Students, faculty, and staff at the U of I may log in with your NetID and password to view the item. If you are trying to access an Illinois-restricted dissertation or thesis, you can request a copy through your library's Inter-Library Loan office or purchase a copy directly from ProQuest.
Permalink
https://hdl.handle.net/2142/86308
Description
Title
Isolation and Characterization of a Novel Gene, xMADML, Involved in Xenopus Laevis Eye Development Using Cornea -Lens Regeneration
Author(s)
Elkins, Matthew Brian
Issue Date
2006
Doctoral Committee Chair(s)
Jonathan Joseph Henry
Department of Study
Cell and Developmental Biology
Discipline
Cell and Developmental Biology
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
Biology, Cell
Language
eng
Abstract
One clone was isolated from the cDNA library on the basis of its embryonic expression pattern and its sequence similarity to human NRBP and mouse MADM genes. This gene, xMADML, was characterized through molecular analysis, which showed both similarity and important differences to MADM, and protein knock-down, which showed that xMADML is necessary in both the developing retina and lens. Analysis of the expression patterns of known genes in the xMADML-knockdown background showed that expression of some genes, particularly Pax6, were altered, whereas the expression patterns of other genes were not. This suggests that xMADML is involved in the signaling cascades necessary to control retina and lens development. Further understanding of the genetic controls of eye development will allow for increased understanding of the general process of development.
Use this login method if you
don't
have an
@illinois.edu
email address.
(Oops, I do have one)
IDEALS migrated to a new platform on June 23, 2022. If you created
your account prior to this date, you will have to reset your password
using the forgot-password link below.
