Regulated Subcellular Distribution of Constitutive Androstane Receptor (Car)
Xia, Jun
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Permalink
https://hdl.handle.net/2142/86307
Description
Title
Regulated Subcellular Distribution of Constitutive Androstane Receptor (Car)
Author(s)
Xia, Jun
Issue Date
2006
Doctoral Committee Chair(s)
Kemper, Byron W.
Department of Study
Cell and Developmental Biology
Discipline
Cell and Developmental Biology
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
Biology, Cell
Language
eng
Abstract
Overall, our studies are consistent with a model in which CAR is constantly shuttling between the cytoplasmic and the nucleus with the steady state strongly favoring cytoplasmic localization in untreated animals and strongly favoring nuclear localization in PB-treated animals. Regulation of the subcellular distribution of CAR is much more complicated than generally thought and might involve multiple regulatory factors and signal motifs.
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