Characterization and Efficacy of Cobalt Compounds as in Vivo Magnetic Resonance Temperature Probes
Wilmes, Lisa Jeanne
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https://hdl.handle.net/2142/85485
Description
Title
Characterization and Efficacy of Cobalt Compounds as in Vivo Magnetic Resonance Temperature Probes
Author(s)
Wilmes, Lisa Jeanne
Issue Date
1998
Doctoral Committee Chair(s)
Richard L. Magin
Department of Study
Biophysics
Discipline
Biophysics
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
Biophysics, General
Language
eng
Abstract
This work demonstrates that $\sp{59}$Co NMR can be used to determine temperature changes in vivo. The liposome encapsulated $\rm \lbrack Co(en)\sb3\rbrack Cl\sb3$ and Co(Hp) (Im) $\sb2\sp+$ show promise as in vivo MR temperature probes. The relatively high accumulation of Co(Hp) (Im) $\sb2\sp+$ in tumors indicates that this configuration may have potential for measuring tumor temperature during hyperthermic treatment of cancer.
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