Evolutionary Analysis of Acetylcholine Receptors Type of Ligand-Gated Ion Channels
Tasneem, Asba
This item is only available for download by members of the University of Illinois community. Students, faculty, and staff at the U of I may log in with your NetID and password to view the item. If you are trying to access an Illinois-restricted dissertation or thesis, you can request a copy through your library's Inter-Library Loan office or purchase a copy directly from ProQuest.
Permalink
https://hdl.handle.net/2142/85448
Description
Title
Evolutionary Analysis of Acetylcholine Receptors Type of Ligand-Gated Ion Channels
Author(s)
Tasneem, Asba
Issue Date
2005
Doctoral Committee Chair(s)
Jakobsson, Eric
Department of Study
Biophysics and Computational Biology
Discipline
Biophysics and Computational Biology
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
Biophysics, General
Language
eng
Abstract
"In this thesis I have reconstructed the evolutionary history in animals where I focused on analyzing the complete genomes of seven widely different animals. My strategy of using complete genomes is based on ""absence of evidence is evidence of absence"". Of course there are gaps in the genetic record in general, but by focusing on complete genome analysis, I hoped to minimize the effects of biases in the gaps, and provide a framework for systematic expansion of the work in the future as more complete genomes become available. Within these seven animals, after creating a comprehensive alignment of all the ART-LGIC sequences, I systematically created subclasses based on the alignment, and built a multi-scale branching structure starting with the most likely common ancestor (i.e., consensus) sequence, branching out to the ancestral subfamilies (those that are seen in all seven of the animals), and finally out to the more specialized subfamilies that appeared within particular phyla, as represented by the organisms that I analyzed. I then tracked the location-bylocation transformations by which different subclasses branched from others. By making such a comprehensive map of evolutionary pathways on the background of the amino acid sequences, my intent was to create a resource by which the relationship between sequence and function could be comprehensively explored."
Use this login method if you
don't
have an
@illinois.edu
email address.
(Oops, I do have one)
IDEALS migrated to a new platform on June 23, 2022. If you created
your account prior to this date, you will have to reset your password
using the forgot-password link below.
