A Survey of Beta-Sheet Folding: WW Domains With Zinc Fingers and Membrane Peptides
Nguyen, Houbi Tung Thanh
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https://hdl.handle.net/2142/85441
Description
Title
A Survey of Beta-Sheet Folding: WW Domains With Zinc Fingers and Membrane Peptides
Author(s)
Nguyen, Houbi Tung Thanh
Issue Date
2004
Doctoral Committee Chair(s)
Martin Gruebele
Department of Study
Biophysics and Computational Biology
Discipline
Biophysics and Computational Biology
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
Biophysics, General
Language
eng
Abstract
This work describes the present state of folding research involving small, fast-folding protein systems. By perturbing a WW domain sequence with side-chain mutations, truncations, amide-to-ester exchanges, and loop rearrangements we find that loop structures can dictate the folding dynamics of this model beta-sheet protein. We then report on a synthetic zinc-finger peptide used to bridge the gap between experimental and theoretical protein folding research. To complete our work we summarize ongoing research on the membrane interactions of a small alpha-helical peptide.
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