Regulation of Glycogenolysis in Anaerobic Skeletal Muscle
Hsu, Alexander Chong-Koang
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https://hdl.handle.net/2142/85423
Description
Title
Regulation of Glycogenolysis in Anaerobic Skeletal Muscle
Author(s)
Hsu, Alexander Chong-Koang
Issue Date
2002
Doctoral Committee Chair(s)
Dawson, M. Joan
Department of Study
Biophysics and Computational Biology
Discipline
Biophysics and Computational Biology
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
Biology, Animal Physiology
Language
eng
Abstract
Functional compartmentation of anaerobic metabolism was demonstrated in intact tissue. Force-independent ATP utilization, primarily the Ca 2+ pump of the sarcoplasmic reticulum, preferentially uses ATP derived from glycogenolysis. ATP produced by creatine kinase is used mostly by force-dependent ATP consuming processes, primarily the actomyosin-ATPase. Although prior evidence of sub-cytosolic metabolic compartmentation exists, the majority of these studies are not in intact cells or tissues. The demonstration here of functional compartmentation of ATP production for specific ATPases shows that metabolism needs to be considered with this in mind.
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