Coregulatory Transcription Factors and Spermatogenesis
Morrow, Carla K.
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https://hdl.handle.net/2142/85379
Description
Title
Coregulatory Transcription Factors and Spermatogenesis
Author(s)
Morrow, Carla K.
Issue Date
2008
Doctoral Committee Chair(s)
Hess, Rex A.
Department of Study
Biology
Discipline
Biology
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
Biology, Molecular
Language
eng
Abstract
The BTB was hypothesized to be deficient in Etv5 -/- mice, and that this was mediated by Claudin 5 (CLD5). In both Etv5-/- and W/Wnu mice, the BTB was leaky. Examination of CLD5 expression among mice of various ages and phenotypes revealed the following: both ETV5 and germ cells were necessary for seminiferous epithelial CLD5 expression; CLD5 expression was ETV5 independent in vascular endothelium; and CLD5 was expressed in both Sertoli cells and spermatogonia. Data presented here support the conclusion that Sertoli cell CLD5 has a role in BTB function, but also a non-tight junction role in spermatogonia.
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