University of Illinois Urbana-Champaign

Evaluation of Metabolic Endpoints for Use as Biomarkers of Exposure to Environmental Estrogens and in Bioassays of Their Activity

Dean-Colomb, Windy

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https://hdl.handle.net/2142/85351

Description

Title
Evaluation of Metabolic Endpoints for Use as Biomarkers of Exposure to Environmental Estrogens and in Bioassays of Their Activity
Author(s)
Dean-Colomb, Windy
Issue Date
2004
Doctoral Committee Chair(s)
Jeffery, Elizabeth H.
Department of Study
Biology
Discipline
Biology
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
Environmental Sciences
Language
eng
Abstract
These findings indicate that angiotensinogen and uterine complement C3 can serve as sensitive indicators of estrogenicity. Additionally, angiotensinogen has the potential to be a biomarker of exposure to estrogenic compounds because its measurement only requires a blood sample, while providing a sensitive biochemical endpoint to supplement the uterotrophic assay. Nevertheless, other endpoints that can be used as potential biomarkers of environmental estrogen exposure are still needed since angiotensinogen is not specific to estrogens and thus cannot be used alone.
Graduation Semester
2004
Type of Resource
text
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http://hdl.handle.net/2142/85351

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