Development and Evaluation of a Physiologically Based Pharmacokinetic Model of Fentanyl in Dogs
Grimm, Kurt Allan
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Permalink
https://hdl.handle.net/2142/85344
Description
Title
Development and Evaluation of a Physiologically Based Pharmacokinetic Model of Fentanyl in Dogs
Author(s)
Grimm, Kurt Allan
Issue Date
2002
Doctoral Committee Chair(s)
David R. Gross
Department of Study
Biology
Discipline
Biology
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
Biology, Animal Physiology
Language
eng
Abstract
Results of the bioequivalence analysis indicated the model was not equivalent. The model was examined using time averaged inputs of tissue blood flows and using stepped changes in tissue blood flow representing measured changes in individual experimental subjects. Analysis of partial areas under the curve suggested the model was better at predicting the elimination than the distribution of fentanyl, although the partial areas under the curve were still not equivalent.
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