In Vitro Effects of Actively Delivered Coencapsulated Curcumin and Cisplatin Nanoliposomes on Squamous Oral Carcinoma
Gosangari, Saujanya Laxmirajam
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https://hdl.handle.net/2142/85223
Description
Title
In Vitro Effects of Actively Delivered Coencapsulated Curcumin and Cisplatin Nanoliposomes on Squamous Oral Carcinoma
Author(s)
Gosangari, Saujanya Laxmirajam
Issue Date
2008
Doctoral Committee Chair(s)
Kenneth L. Watkin
Department of Study
Speech and Hearing Science
Discipline
Speech and Hearing Science
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
Health Sciences, Pharmacy
Language
eng
Abstract
Multidrug carriers were also formulated using a Dipalmitoyl Phosphatidylcholine (DPPC) as a primary lipid, with incorporation of a lysolipid to achieve controlled release of the drugs loaded within. Diagnostic ultrasound energy was then employed as a tool to achieve controlled release from the newly developed multidrug carriers at a frequency of 7.5 MHz and four different power intensities depending on the pulse repetition time. The optimal lipid composition and the intensity settings of ultrasound energy were chosen to formulate a new class of nanoliposomes---ultrasound sensitive nanoliposomes (USNL). The USNLs released increasing amounts of drug in response to increasing irradiation times while the drug release was not significant when the Non-USNLs were exposed to ultrasound energy levels. In vitro studies to test the cytotoxicity of the formulations showed that the USNLs significantly inhibited cell survival of SCC9 oral cancer cells, as compared to the Non-USNLs. We hypothesize that the drug is released due to increased membrane permeability during exposure to ultrasound energy. The lipid composition and energy levels play a key role in determining the efficacy of diagnostic ultrasound energy as a tool for drug delivery. Thus the novel chemotherapeutic approach with the use of compound liposomes, when combined with an active delivery modality can be employed as the primary treatment rather then opting for cosmetically harsh surgery. This may also help in better organ preservation and functioning, which in turn would improve the overall quality of life in patients with these tumors.
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