Small Gadolinium Oxide Contrast Agents: A Novel Class of Multi-Modality Contrast and Therapeutic Agents
McDonald, Michael Alexander
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https://hdl.handle.net/2142/85205
Description
Title
Small Gadolinium Oxide Contrast Agents: A Novel Class of Multi-Modality Contrast and Therapeutic Agents
Author(s)
McDonald, Michael Alexander
Issue Date
2004
Doctoral Committee Chair(s)
Kenneth Watkin
Department of Study
Speech and Hearing Science
Discipline
Speech and Hearing Science
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
Health Sciences, Radiology
Language
eng
Abstract
Towards this aim experimental studies will be presented for the biophysical characterization of gadolinium oxide particulate contrast agents as a novel class of prototype multi-modality contrast agent. In chapter 2 an analysis of the MR contrast enhancement and X-ray attenuation properties of small particulate gadolinium oxide and gadolinium oxide albumin microspheres for MR and CT imaging is presented. MR relaxometry and nuclear magnetic relaxation dispersion (NMRD) characterization of the water-proton relaxation properties of small particulate gadolinium oxide and gadolinium oxide albumin microspheres is provided in chapter 3. In chapter 4 the structure and magnetic properties of dextran small particulate gadolinium oxide nanoparticles are explored in order to provide insight into their potential use as high magnetic field strength MR contrast agents and to elucidate their potential for improvement of SPGO water-proton relaxation. In chapter 5, speed of sound, attenuation, backscatter and video density studies are presented to characterize the acoustic properties of gadolinium oxide albumin microspheres (paramagnetic polymerized protein microspheres) for use as a contrast enhancing agent in US imaging.
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