Comparative Cytotoxicity and Genotoxicity of Drinking Water Disinfection by -Products
Kargalioglu, Yahya
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https://hdl.handle.net/2142/85000
Description
Title
Comparative Cytotoxicity and Genotoxicity of Drinking Water Disinfection by -Products
Author(s)
Kargalioglu, Yahya
Issue Date
2002
Doctoral Committee Chair(s)
Plewa, Michael J.
Department of Study
Crop Sciences
Discipline
Crop Sciences
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
Biology, Microbiology
Language
eng
Abstract
The quantitative rank order of the cytotoxicity and genotoxicity of the DBPs showed that brominated haloacetic acids were more genotoxic than their chlorinated analogs in mammalian cells. The difference in the responses to DBPs by bacterial and mammalian cells suggests that the relative risks based on Salmonella alone should be questioned. The in vitro microplate based bacterial and mammalian assays developed and used in this research can be employed for screening other important chemicals in the environment.
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