Testosterone, Lycopene Isomers, and Prostate Cancer
Boileau, Thomas William-Maxwell
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https://hdl.handle.net/2142/84992
Description
Title
Testosterone, Lycopene Isomers, and Prostate Cancer
Author(s)
Boileau, Thomas William-Maxwell
Issue Date
2001
Doctoral Committee Chair(s)
John W. Erdman, Jr.
Department of Study
Nutritional Sciences
Discipline
Nutritional Sciences
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
Health Sciences, Oncology
Language
eng
Abstract
The objective of the final study was to determine the influence of purified lycopene, tomato powder, and 20% diet restriction on N-methyl-N-nitrosourea (NMU)-testosterone-induced prostate cancer in rats. Survival was analyzed to include only rats that died with adenocarcinomas of the accessory sex glands. Only tomato powder-fed (RR = 0.570; P = 0.009) rats experienced significantly increased survival as compared to placebo beadlet-fed control rats. No significant influences of lycopene beadlet feeding or diet restriction as well as no interactions were noted for accessory sex gland-specific survival. We conclude that tomato powder may contain compounds, in addition to lycopene, which favorably modulate prostate carcinogenesis.
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