Orally Administered IGF -I Combined With Partial Enteral Nutrition Alters Intestinal Morphology and Disaccharidase Activity During Parenteral Nutrition in Neonatal Piglets

Park, Yoo Kyoung

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Description

Title

Orally Administered IGF -I Combined With Partial Enteral Nutrition Alters Intestinal Morphology and Disaccharidase Activity During Parenteral Nutrition in Neonatal Piglets

Author(s)

Park, Yoo Kyoung

Issue Date

1999

Doctoral Committee Chair(s)

Donovan, Sharon M.

Department of Study

Nutritional Sciences

Discipline

Nutritional Sciences

Degree Granting Institution

University of Illinois at Urbana-Champaign

Degree Name

Ph.D.

Degree Level

Dissertation

Keyword(s)

Agriculture, Animal Culture and Nutrition

Language

eng

Abstract

Our final study investigated the mechanism(s) by which IGF-I up-regulates LPH activity. The three treatment groups were: 100% TPN, 20% PEN with or without 1.0 mg/kg IGF-I. IGF-I increased LPH activity and LPH activity per unit mature LPH ∼2-fold over PEN alone, but did not affect LPH mRNA or the relative abundance of proLPHh or mature LPH. Fractional and absolute synthesis rates of mucosal protein and LPH were similar among the treatment groups. Total mucosal protein synthesis was increased 60% in the IGF-I treated animals. Based on these data, we speculate that the mechanism by which IGF-I up-regulates LPH is post-translational, either via reducing LPH degradation or specifically altering LPH enzyme kinetics.

Graduation Semester

1999

Type of Resource

text

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