Intestinal Uptake of Carotenoids: Implications for Carotenoid Bioavailability
Boileau, Amy Christine
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https://hdl.handle.net/2142/84984
Description
Title
Intestinal Uptake of Carotenoids: Implications for Carotenoid Bioavailability
Author(s)
Boileau, Amy Christine
Issue Date
1999
Doctoral Committee Chair(s)
John W. Erdman, Jr.
Department of Study
Nutritional Sciences
Discipline
Nutritional Sciences
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
Health Sciences, Public Health
Language
eng
Abstract
Lycopene is the predominant carotenoid in tomatoes and tomato-based foods and is also a predominant carotenoid in human serum and tissues. The observation that serum and tissue lycopene is more than 50% cis-lycopene, whereas tomatoes and tomato-based foods contain mainly all-trans lycopene, has led to the hypothesis that cis-isomers of lycopene are more bioavailable. When bile acid micelles were prepared in vitro from crystalline lycopene, cis-isomers of lycopene were significantly enriched in the optically-clear micelle preparation. Mesenteric lymph duct cannulated ferrets were used to study the in vivo absorption of lycopene. Following an oral dose, lymph was collected for 2 hours. The lymph secretions contained a significantly greater proportion of cis-lycopene than any other fraction (P < 0.01). These studies demonstrate that in ferrets, cis-isomers of lycopene are more bioavailable than the all-trans isomer.
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