The Effect of Ethanol and Acetaldehyde on Formation and Repair of Carcinogen-Dna Adducts in the Mammary Gland
Barnes, Sean Lenard
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https://hdl.handle.net/2142/84983
Description
Title
The Effect of Ethanol and Acetaldehyde on Formation and Repair of Carcinogen-Dna Adducts in the Mammary Gland
Author(s)
Barnes, Sean Lenard
Issue Date
1999
Doctoral Committee Chair(s)
Singletary, Keith W.
Department of Study
Nutritional Sciences
Discipline
Nutritional Sciences
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
Health Sciences, Toxicology
Language
eng
Abstract
In conclusion, both ethanol and acetaldehyde are capable of enhancing carcinogen-DNA adduct formation and inhibiting removal. However, these effects are dependent on the concentrations of ethanol or acetaldehyde, the time of exposure and the dose of carcinogen. Additionally, these effects, particularly those related to adduct formation, may be explained by either decreases in levels of carcinogen-detoxifying enzymes or an overall increase in oxidative stress.
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