Metabolic Responses During Recovery From Prolonged Exercise: Role of Nutrition and Hormones
Gautsch, Tracy Anne
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https://hdl.handle.net/2142/84979
Description
Title
Metabolic Responses During Recovery From Prolonged Exercise: Role of Nutrition and Hormones
Author(s)
Gautsch, Tracy Anne
Issue Date
1998
Doctoral Committee Chair(s)
Layman, Donald K.
Department of Study
Nutritional Sciences
Discipline
Nutritional Sciences
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
Health Sciences, Rehabilitation and Therapy
Language
eng
Abstract
The second specific aim of this research was to investigate the regulation of insulin-like growth factor binding protein-1 production following exercise. Prolonged exercise increased plasma and hepatic levels of IGFBP-1. Neither plasma insulin and glucose levels, nor meal composition altered IGFBP-1 production following exercise. Conversely, adaptation to treadmill running markedly suppressed IGFBP-1 production, suggesting a connection between exercise stress and IGFBP-1. Further, plasma corticosterone correlated to plasma IGFBP-1 in untrained and treadmill-adapted animals following exercise. However, pre-treatment with drugs that block corticosterone synthesis and bioactivity did not prevent IGFBP-1 from rising following exercise. These results demonstrate that upregulation of IGFBP-1 following exercise is corticosteroid-independent. Further research is needed to determine the chemical factor(s) inducing IGFBP-1 production following exercise.
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