Molecular Dissection of Interferon-Gamma Treated Pancreatic Beta-Cells
Baldeon, Manuel Eduardo
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https://hdl.handle.net/2142/84978
Description
Title
Molecular Dissection of Interferon-Gamma Treated Pancreatic Beta-Cells
Author(s)
Baldeon, Manuel Eduardo
Issue Date
1998
Doctoral Committee Chair(s)
Gaskins, H. Rex
Department of Study
Nutritional Sciences
Discipline
Nutritional Sciences
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
Biology, Animal Physiology
Language
eng
Abstract
Conclusions. Interferon-$\gamma,$ but not IFN-$\alpha,$ has a direct pathogenic role on the pancreatic $\beta$-cell. Early expression of IFN-$\alpha$ by the $\beta$-cell may contribute to insulitis whereas IFN-$\gamma,$ a product of islet infiltrating leukocytes, may mediate characteristic decreases in glucose sensitivity and increased cell surface expression of MHC class $\rm I\sb{A}$ in the prediabetic $\beta$-cell. Enhanced expression of the MHC class $\rm I\sb{A}$ antigen processing and presentation pathway and diminished insulin production appear to be distinct pathologic alterations in $\beta$-cells exposed to the insulitic cytokine IFN-$\gamma.$.
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